Generate Clinically-relevant Functional Data with 3D Tissues
Mantarray brings functional data into the earliest stages of preclinical testing of new medicines.
By providing parallel analysis of 3D engineered muscle tissues with adult-like functional profiles, Mantarray enables the discovery, safety, and efficacy testing of new therapeutics.
Meet Mantarray™
Measure Key Metrics in Your Lab
- Force Frequency
- Rate of Contraction/Systole
- Rate of Relaxation/Diastole
- Time to Max Twitch (Peak)
- Maximal Twitch Amplitude
- Full Width at Half Max
Mantarray Instrument
Skeletal Muscle & Cardiac Applications for Drug Studies & Disease Modeling
The Mantarray platform provides an easy-to-use, scalable, and flexible system that allows researchers to examine 3D tissues in vitro in the convenience of their own lab.
Compact (Fits in Incubator)
Individual Stimulation Capabilities
Tissue Temperature Control (Cooling Unit)
Easy 3D Tissue Building
Cloud Platform (Simplifies Data Capture & Analysis)
Contact us to inquire about getting a Mantarray Instrument in your lab.
Mantarray Software Preview (click to enlarge)
Application
Disease Modeling & Therapeutic Discovery
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Isogenic controls or corrected cell lines can be used to provide clear stratification between healthy and diseased phenotypes. Stratifying differences between healthy disease model EHTs provides a platform for discovery and validation of new therapeutics. Validate new therapies using human models of muscle contractility.
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Complex diseases require complex models. 3D Engineered Muscle Tissues (EMTs) can be made from human iPSC-derived cells with healthy and diseased phenotypes and used to test whether a new therapy will improve or recover healthy contraction. For example, DMD tissues show significant contractile deficits and greater fatigue compared to isogenic control EMTs.
Application
Safety Screening
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The magnetic detection approach can measure both acute (minutes) and chronic (days) drug responses. Drugs such as isoproterenol can be measured on the order of seconds to minutes, with enough sensitivity to measure dose response-like behavior. Additionally, longer-term chronic experiments such as doxorubicin can be performed over the course of days.
Talk to our team of experts today to learn more about our safety screening services.
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Mantarray Consumables
Mantarray Plate Kit
Easily Form 3D Tissues in Your Lab
With over 95% tissue formation success rate, the Mantarray Plate Kit allows for reliable and reproducible engineered tissues across 24 wells.
Mantarray Stimulation Kit
Fully Customizable Electrical Stimulation
Utilizing this lid with the Mantarray instrument enables individual stimulation protocols for each well, for both acute and long-term pacing.
MantaReady Media Kits
Optimize Your 3D Tissue Casting Experience
Curi Bio's proprietary serum-free medium provides longer culture times and stronger contractile force. Available for iPSC and Primary cell types.
More Mantarray Resources
Read Publications
Learn More About Mantarray
Want to apply Mantarray to your projects? Bring 3D EMTs into Your Lab. Partner with Curi Bio.
If you are interested in learning more about how Mantarray can accelerate your research, please contact us to arrange a conversation with our team of experts.