3D Engineered Muscle Tissues
3D Engineered Muscle Tissues (EMTs) Enable in vitro Models of Skeletal Muscle Contractility
Allows assessment of changes to tissue function in response to disease or drug treatment.
Tissue responses to drugs can be monitored on short (minutes) or long (days) timescales.
Label-free measurement technique capable of direct contractility assessment across 24 tissues in parallel.
Reliable and reproducible tissue casting across entire plate (over 90% success rate).
Learn more about Mantarray – Curi Bio’s novel 3D Engineered Muscle Tissue platform that uses facile and scalable bioengineering approaches to generate tissues from a variety of cell sources, and a label-free parallel measurement technique:
Key Metrics
- Contractile Force (different figure)
- Force Frequency (different figure)
- Rate of Contraction
- Rate of Relaxation
- Time to Max Twitch (Peak)
- Maximal Twitch Amplitude
- Full Width at Half Max
More detailed display of metrics that can be generated using Curi Bio’s Mantarray Platform.
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Application Examples
3D Engineered Muscle Tissues features using Curi Bio’s Mantarray Platform.
Data Analysis
Simultaneous analysis of data from all 24 wells using Curi Bio’s custom data package.
Easily accessible user report showing clinically relevant functional data.
Toxicology Screening
Tissue responses to drugs can be monitored on short (minutes) or long (days) timescales.
High throughput measurement technique capable of direct contractility assessment across 24 tissues in parallel.
Disease Modeling
Generation of a physiologically relevant neuromuscular junctions to model hereditary neuromuscular diseases.
Derivation of an ultra-rare patient specific Duchenne’s Muscular Dystrophy models for personalized gene therapy.
The Mantarray Platform brings functional data into the earliest stages of preclinical testing of new medicines.
Learn more about how Curi Bio’s Mantarray Platform can benefit your lab:
Curi Bio’s Mantarray Instrument
2D Skeletal Muscle Model
Structurally Matured, Aligned Skeletal Microtissues
Curi Bio's 2D skeletal muscle model utilizes microtissues built by structurally maturing human skeletal muscle cells in biomimetic NanoSurface™ Plates. Structurally mature skeletal microtissues can be engineered from many cell lines – including commercial lines and disease lines – and can be used with a wide range of assay formats and screening workflows.
Skeletal muscle tissues plated on NanoSurface technology are more structurally and functionally mature than standard models from the same cell source, exhibiting:
High throughput screening output
Can be paired with 3D model system for higher functional relevance
Learn more about NanoSurface technology:
Application Examples
NanoSurface Plates Enhance the Structural Development of Cells and Tissues, Improving the Physiological Relevance of Cell-based Assays
Learn more about Curi Bio’s NanoSurface Plates and how they can benefit your lab:
Curi Bio's 384-well NanoSurface Plate